Selena explains that he's crashing from the sugar in the soda he'd been drinking for the past few days. About halfway up the stairs, Jim has to stop because he has a pounding headache. They see Christmas lights blinking in a high-rise tenement and go to check it out. She warns that should he become infected, she will kill him 'in a heartbeat.' As the two journey through the derelict city the next day, Selena rules out intimacy between her and Jim, declaring that only the fight for survival remains. Selena immediately hacks him to death with a machete, explaining to Jim that infection is spread through contact with contaminated blood and overwhelms its victims in seconds, rendering them deadly to others. That night, several Infected attack the survivors, and when the fight ends, Mark is bleeding. He discovers that his parents committed suicide. Though they think it's a bad plan, Selena and Mark accompany Jim. Jim insists on going to his parents' house. They reveal that while Jim was comatose, the virus spread uncontrollably among the populace, turning most people into vicious murderers ('the Infected') and resulting in societal collapse, possibly on a global scale. He's chased through the streets by the infected people before being rescued by two survivors, Selena ( Naomie Harris) and Mark ( Noah Huntley), who rush him to their hideout in the London Underground, using explosive charges attached to gasoline pumps to cover their escape. He quickly discovers that the people are raging monsters who attack him. While he wanders the streets, calling out for anyone who might still be around, he finds a church where a large group of people have gathered. As he leaves the hospital, he discovers London is completely deserted and rife with signs of catastrophe. Twenty-eight days later, a bicycle courier named Jim ( Cillian Murphy) awakens from a coma in a deserted hospital. The infection seems to spread very quickly through its victims, turning them into uncontrollable monsters in a matter of seconds.

Disregarding the warnings of a lab staffer, the activists ultimately free the Rage virus subjects, which attack and infect the activists and scientist. Late one night, British animal rights activists break into a laboratory to free chimpanzees being used for medical research.The synopsis below may give away important plot points.

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